Biological, Biochemical, and Molecular Characterization of a New Clinical Trichophyton rubrum Isolate Resistant to Terbinafine

We have characterized a new clinical strain of Trichophyton rubrum highly resistant to terbinafine but exhibiting normal susceptibility to drugs with other mechanisms of action. Resistance to terbinafine in this strain is caused by a missense mutation in the squalene epoxidase gene leading to the am...

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Bibliographic Details
Main Authors: Osborne, Colin S., Leitner, Ingrid, Hofbauer, Bettina, Fielding, Ceri A., Favre, Bertrand, Ryder, Neil S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479141/
https://ncbi.nlm.nih.gov/pubmed/16723593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01600-05
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