Characterization of Squalene Epoxidase of Saccharomyces cerevisiae by Applying Terbinafine-Sensitive Variants

Squalene epoxidase (SE) is the target of terbinafine, which specifically inhibits the fungal enzyme in a noncompetitive manner. On the basis of functional homologies to p-hydroxybenzoate hydroxylase (PHBH) from Pseudomonas fluorescens, the Erg1 protein contains two flavin adenine dinucleotide (FAD)...

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Auteurs principaux: Ruckenstuhl, Christoph, Lang, Silvia, Poschenel, Andrea, Eidenberger, Armin, Baral, Pravas Kumar, Kohút, Peter, Hapala, Ivan, Gruber, Karl, Turnowsky, Friederike
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2007
Sujets:
Mechanisms of Resistance
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797698/
https://ncbi.nlm.nih.gov/pubmed/17043127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00988-06
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