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A Recombinant Influenza A Virus Expressing an RNA-Binding-Defective NS1 Protein Induces High Levels of Beta Interferon and Is Attenuated in Mice

Previously we found that the amino-terminal region of the NS1 protein of influenza A virus plays a key role in preventing the induction of beta interferon (IFN-β) in virus-infected cells. This region is characterized by its ability to bind to different RNA species, including double-stranded RNA (dsR...

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Udgivet i:J Virol
Principais autores: Donelan, Nicola R., Basler, Christopher F., García-Sastre, Adolfo
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2003
Fag:
Virus-Cell Interactions
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296096/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14645582/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.24.13257-13266.2003
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