Mucosal Immunization with Live Recombinant Bovine Respiratory Syncytial Virus (BRSV) and Recombinant BRSV Lacking the Envelope Glycoprotein G Protects against Challenge with Wild-Type BRSV

Recombinant bovine respiratory syncytial virus (rBRSV) and an rBRSV deletion mutant lacking the G gene (rBRSVΔG) were characterized in calves with respect to replication competence, attenuation, and protective efficacy as live-attenuated BRSV vaccines. Both recombinant viruses were safe and induced...

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Detalhes bibliográficos
Main Authors: Schmidt, Ulrike, Beyer, Jörg, Polster, Ulf, Gershwin, Laurel J., Buchholz, Ursula J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC136874/
https://ncbi.nlm.nih.gov/pubmed/12414977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.23.12355-12359.2002
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