Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: essential roles of CYP2A5 and target-tissue metabolic activation

The herbicide 2,6-dichlorobenzonitril (DCBN) is a potent and tissue-specific toxicant to the olfactory mucosa (OM). The toxicity of DCBN is mediated by cytochrome P450 (P450)-catalyzed bioactivation; however, it is not known whether target-tissue metabolic activation is essential for toxicity. CYP2A...

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Hlavní autoři: Xie, Fang, Zhou, Xin, Behr, Melissa, Fang, Cheng, Horii, Yuichi, Gu, Jun, Kannan, Kurunthachalam, Ding, Xinxin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956786/
https://ncbi.nlm.nih.gov/pubmed/20840855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2010.09.003
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