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Bioactivation of the Nasal Toxicant 2,6-Dichlorobenzonitrile: An Assessment of Metabolic Activity in Human Nasal Mucosa and Identification of Indicators of Exposure and Potential Toxicity

The herbicide 2,6-dichlorobenzonitrile (DCBN) is a potent nasal toxicant in rodents; however it is not known whether DCBN causes similar nasal toxicity in humans. The tissue-selective toxicity of DCBN in mouse nasal mucosa is largely dependent on target tissue bioactivation by CYP2A5. The human orth...

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Detalhes bibliográficos
Main Authors: Xie, Fang, D’Agostino, Jaime, Zhou, Xin, Ding, Xinxin
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602354/
https://ncbi.nlm.nih.gov/pubmed/23360412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx300479w
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