Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: essential roles of CYP2A5 and target-tissue metabolic activation

The herbicide 2,6-dichlorobenzonitril (DCBN) is a potent and tissue-specific toxicant to the olfactory mucosa (OM). The toxicity of DCBN is mediated by cytochrome P450 (P450)-catalyzed bioactivation; however, it is not known whether target-tissue metabolic activation is essential for toxicity. CYP2A...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Xie, Fang, Zhou, Xin, Behr, Melissa, Fang, Cheng, Horii, Yuichi, Gu, Jun, Kannan, Kurunthachalam, Ding, Xinxin
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956786/
https://ncbi.nlm.nih.gov/pubmed/20840855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2010.09.003
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares