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Mechanisms of permanent loss of olfactory receptor neurons induced by the herbicide 2,6-dichlorobenzonitrile: effects on stem cells and noninvolvement of acute induction of the inflammatory cytokine IL-6

We explored the mechanisms underlying the differential effects of two olfactory toxicants, the herbicide 2,6-dichlorobenzonitrile (DCBN) and the anti-thyroid drug methimazole (MMZ), on olfactory receptor neuron (ORN) regeneration in mouse olfactory epithelium (OE). DCBN, but not MMZ, induced inflamm...

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Detalhes bibliográficos
Main Authors: Xie, Fang, Fang, Cheng, Schnittke, Nikolai, Schwob, James E., Ding, Xinxin
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3805741/
https://ncbi.nlm.nih.gov/pubmed/23921153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2013.07.020
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