The Tissue-Specific Toxicity of Methimazole in the Mouse Olfactory Mucosa Is Partly Mediated through Target-Tissue Metabolic Activation by CYP2A5

The antithyroid drug methimazole (MMZ) can cause severe, tissue-specific toxicity in mouse olfactory mucosa (OM), presumably through a sequential metabolic activation of MMZ by cytochrome P450 (P450) and flavin monooxygenases (FMO). The aims of this study were to determine whether CYP2A5, one of the...

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Hlavní autoři: Xie, Fang, Zhou, Xin, Genter, Mary Beth, Behr, Melissa, Gu, Jun, Ding, Xinxin
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2011
Témata:
Short Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100904/
https://ncbi.nlm.nih.gov/pubmed/21415250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.037895
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