Essential Role of the Cytochrome P450 Enzyme CYP2A5 in Olfactory Mucosal Toxicity of Naphthalene

Naphthalene (NA), a ubiquitous environmental pollutant that can cause pulmonary and nasal toxicity in laboratory animals, requires cytochrome P450 (P450)–mediated metabolic activation to cause toxicity. Our recent study using a Cyp2f2-null mouse showed that CYP2F2 plays an essential role in NA-induc...

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Detalhes bibliográficos
Main Authors: Hu, Jinping, Sheng, Li, Li, Lei, Zhou, Xin, Xie, Fang, D’Agostino, Jaime, Li, Yan, Ding, Xinxin
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2014
Assuntos:
Short Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876791/
https://ncbi.nlm.nih.gov/pubmed/24104196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.054429
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