Trehalose-6-Phosphate Phosphatase is required for cell wall integrity and fungal virulence but not trehalose biosynthesis in the human fungal pathogen Aspergillus fumigatus

The trehalose biosynthesis pathway is critical for virulence in human and plant fungal pathogens. In this study, we tested the hypothesis that trehalose-6-phosphate phosphatase (T6PP) is required for Aspergillus fumigatus virulence. A mutant of the A. fumigatus T6PP, OrlA, displayed severe morpholog...

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Autores principales: Puttikamonkul, Srisombat, Willger, Sven D., Grahl, Nora, Perfect, John R., Movahed, Navid, Bothner, Brian, Park, Steven, Paderu, Padmaja, Perlin, David S., Cramer, Robert A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954268/
https://ncbi.nlm.nih.gov/pubmed/20545865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2010.07254.x
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