A Sterol-Regulatory Element Binding Protein Is Required for Cell Polarity, Hypoxia Adaptation, Azole Drug Resistance, and Virulence in Aspergillus fumigatus

At the site of microbial infections, the significant influx of immune effector cells and the necrosis of tissue by the invading pathogen generate hypoxic microenvironments in which both the pathogen and host cells must survive. Currently, whether hypoxia adaptation is an important virulence attribut...

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Main Authors: Willger, Sven D., Puttikamonkul, Srisombat, Kim, Kwang-Hyung, Burritt, James B., Grahl, Nora, Metzler, Laurel J., Barbuch, Robert, Bard, Martin, Lawrence, Christopher B., Cramer, Robert A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2008
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Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2572145/
https://ncbi.nlm.nih.gov/pubmed/18989462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000200
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