Trehalose-6-Phosphate Phosphatase is required for cell wall integrity and fungal virulence but not trehalose biosynthesis in the human fungal pathogen Aspergillus fumigatus

The trehalose biosynthesis pathway is critical for virulence in human and plant fungal pathogens. In this study, we tested the hypothesis that trehalose-6-phosphate phosphatase (T6PP) is required for Aspergillus fumigatus virulence. A mutant of the A. fumigatus T6PP, OrlA, displayed severe morpholog...

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Detalhes bibliográficos
Main Authors: Puttikamonkul, Srisombat, Willger, Sven D., Grahl, Nora, Perfect, John R., Movahed, Navid, Bothner, Brian, Park, Steven, Paderu, Padmaja, Perlin, David S., Cramer, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954268/
https://ncbi.nlm.nih.gov/pubmed/20545865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2010.07254.x
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