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Trehalose-6-Phosphate Phosphatase is required for cell wall integrity and fungal virulence but not trehalose biosynthesis in the human fungal pathogen Aspergillus fumigatus

The trehalose biosynthesis pathway is critical for virulence in human and plant fungal pathogens. In this study, we tested the hypothesis that trehalose-6-phosphate phosphatase (T6PP) is required for Aspergillus fumigatus virulence. A mutant of the A. fumigatus T6PP, OrlA, displayed severe morpholog...

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Bibliografiske detaljer
Main Authors: Puttikamonkul, Srisombat, Willger, Sven D., Grahl, Nora, Perfect, John R., Movahed, Navid, Bothner, Brian, Park, Steven, Paderu, Padmaja, Perlin, David S., Cramer, Robert A.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954268/
https://ncbi.nlm.nih.gov/pubmed/20545865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2010.07254.x
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