Tracking the Evolution of Multiple In Vitro Hepatitis C Virus Replicon Variants under Protease Inhibitor Selection Pressure by 454 Deep Sequencing

Resistance to hepatitis C virus (HCV) inhibitors targeting viral enzymes has been observed in in vitro replicon studies and during clinical trials. The factors determining the emergence of resistance and the changes in the viral quasispecies population under selective pressure are not fully understo...

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Hlavní autoři: Verbinnen, Thierry, Van Marck, Herwig, Vandenbroucke, Ina, Vijgen, Leen, Claes, Marijke, Lin, Tse-I, Simmen, Kenneth, Neyts, Johan, Fanning, Gregory, Lenz, Oliver
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2010
Témata:
Genetic Diversity and Evolution
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953167/
https://ncbi.nlm.nih.gov/pubmed/20739521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01217-10
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