Tracking the Evolution of Multiple In Vitro Hepatitis C Virus Replicon Variants under Protease Inhibitor Selection Pressure by 454 Deep Sequencing

Resistance to hepatitis C virus (HCV) inhibitors targeting viral enzymes has been observed in in vitro replicon studies and during clinical trials. The factors determining the emergence of resistance and the changes in the viral quasispecies population under selective pressure are not fully understo...

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Bibliographische Detailangaben
Hauptverfasser: Verbinnen, Thierry, Van Marck, Herwig, Vandenbroucke, Ina, Vijgen, Leen, Claes, Marijke, Lin, Tse-I, Simmen, Kenneth, Neyts, Johan, Fanning, Gregory, Lenz, Oliver
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2010
Schlagworte:
Genetic Diversity and Evolution
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953167/
https://ncbi.nlm.nih.gov/pubmed/20739521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01217-10
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