Tracking the Evolution of Multiple In Vitro Hepatitis C Virus Replicon Variants under Protease Inhibitor Selection Pressure by 454 Deep Sequencing

Resistance to hepatitis C virus (HCV) inhibitors targeting viral enzymes has been observed in in vitro replicon studies and during clinical trials. The factors determining the emergence of resistance and the changes in the viral quasispecies population under selective pressure are not fully understo...

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Main Authors: Verbinnen, Thierry, Van Marck, Herwig, Vandenbroucke, Ina, Vijgen, Leen, Claes, Marijke, Lin, Tse-I, Simmen, Kenneth, Neyts, Johan, Fanning, Gregory, Lenz, Oliver
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Genetic Diversity and Evolution
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953167/
https://ncbi.nlm.nih.gov/pubmed/20739521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01217-10
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