In Vitro Activity of Simeprevir against Hepatitis C Virus Genotype 1 Clinical Isolates and Its Correlation with NS3 Sequence and Site-Directed Mutants

Simeprevir (TMC435) is a once-daily, single-pill, oral hepatitis C virus (HCV) NS3 protease inhibitor approved for the treatment of chronic HCV infection. Phenotypic characterization of baseline isolates and isolates from HCV genotype 1-infected patients failing with a simeprevir-based regimen was p...

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Udgivet i:Antimicrob Agents Chemother
Main Authors: Verbinnen, Thierry, Fevery, Bart, Vijgen, Leen, Jacobs, Tom, De Meyer, Sandra, Lenz, Oliver
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649234/
https://ncbi.nlm.nih.gov/pubmed/26392483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01444-15
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