Probing the Conformation of a Prion Protein Fibril with Hydrogen Exchange

A fragment of the prion protein, PrP(89–143, P101L), bearing a mutation implicated in familial prion disease, forms fibrils that have been shown to induce prion disease when injected intracerebrally into transgenic mice expressing full-length PrP containing the P101L mutation. In this study, we util...

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Autores principales: Damo, Steven M., Phillips, Aaron H., Young, Anisa L., Li, Sheng, Woods, Virgil L., Wemmer, David E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952231/
https://ncbi.nlm.nih.gov/pubmed/20679344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.114504
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