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Distinct Structures of Scrapie Prion Protein (PrP(Sc))-seeded Versus Spontaneous Recombinant Prion Protein Fibrils Revealed by Hydrogen/Deuterium Exchange
The detailed structures of prion disease-associated, partially protease-resistant forms of prion protein (e.g. PrP(Sc)) are largely unknown. PrP(Sc) appears to propagate itself by autocatalyzing the conformational conversion and oligomerization of normal prion protein (PrP(C)). One manifestation of...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2782017/ https://ncbi.nlm.nih.gov/pubmed/19596861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.036558 |
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