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Distinct Structures of Scrapie Prion Protein (PrP(Sc))-seeded Versus Spontaneous Recombinant Prion Protein Fibrils Revealed by Hydrogen/Deuterium Exchange

The detailed structures of prion disease-associated, partially protease-resistant forms of prion protein (e.g. PrP(Sc)) are largely unknown. PrP(Sc) appears to propagate itself by autocatalyzing the conformational conversion and oligomerization of normal prion protein (PrP(C)). One manifestation of...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Smirnovas, Vytautas, Kim, Jae-Il, Lu, Xiaojun, Atarashi, Ryuichiro, Caughey, Byron, Surewicz, Witold K.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2009
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782017/
https://ncbi.nlm.nih.gov/pubmed/19596861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.036558
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