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Actin Isoform-specific Conformational Differences Observed with Hydrogen/Deuterium Exchange and Mass Spectrometry

Actin can exist in multiple conformations necessary for normal function. Actin isoforms, although highly conserved in sequence, exhibit different biochemical properties and cellular roles. We used amide proton hydrogen/deuterium (HD) exchange detected by mass spectrometry to analyze conformational d...

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Bibliografiske detaljer
Main Authors: Stokasimov, Ema, Rubenstein, Peter A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757243/
https://ncbi.nlm.nih.gov/pubmed/19605362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.013078
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