Probing the Conformation of a Prion Protein Fibril with Hydrogen Exchange

A fragment of the prion protein, PrP(89–143, P101L), bearing a mutation implicated in familial prion disease, forms fibrils that have been shown to induce prion disease when injected intracerebrally into transgenic mice expressing full-length PrP containing the P101L mutation. In this study, we util...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Damo, Steven M., Phillips, Aaron H., Young, Anisa L., Li, Sheng, Woods, Virgil L., Wemmer, David E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952231/
https://ncbi.nlm.nih.gov/pubmed/20679344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.114504
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky