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In Vitro Reconstitution of the Selection, Ubiquitination, and Membrane Extraction of a Polytopic ERAD Substrate

Secretory and membrane proteins that are destined for intracellular organelles in eukaryotes are first synthesized at the endoplasmic reticulum (ER) and are then delivered to their final destinations. The ER contains high concentrations of molecular chaperones and folding enzymes that assist substra...

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Detalhes bibliográficos
Main Authors: Nakatsukasa, Kunio, Brodsky, Jeffrey L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950970/
https://ncbi.nlm.nih.gov/pubmed/20419421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-60327-412-8_21
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