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Subcellular Fractionation Analysis of the Extraction of Ubiquitinated Polytopic Membrane Substrate during ER-Associated Degradation

During ER-associated degradation (ERAD), misfolded polytopic membrane proteins are ubiquitinated and retrotranslocated to the cytosol for proteasomal degradation. However, our understanding as to how polytopic membrane proteins are extracted from the ER to the cytosol remains largely unclear. To bet...

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書目詳細資料
發表在:PLoS One
Main Authors: Nakatsukasa, Kunio, Kamura, Takumi
格式: Artigo
語言:Inglês
出版: Public Library of Science 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743956/
https://ncbi.nlm.nih.gov/pubmed/26849222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148327
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