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Dissecting the ER-associated degradation of a misfolded polytopic membrane protein

It remains unclear how misfolded membrane proteins are selected and destroyed during endoplasmic reticulum associated degradation (ERAD). For example, chaperones are thought to solubilize aggregation-prone motifs, and some data suggest that these proteins are degraded at the ER. To better define how...

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Hlavní autoři: Nakatsukasa, Kunio, Huyer, Gregory, Michaelis, Susan, Brodsky, Jeffrey L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2219389/
https://ncbi.nlm.nih.gov/pubmed/18191224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2007.11.023
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