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BAG6 regulates the quality control of a polytopic ERAD substrate

BAG6 participates in protein quality control and, here, we address its role in endoplasmic-reticulum-associated degradation (ERAD) by using the polytopic membrane protein OpD, an opsin degron mutant. Both BAG6 knockdown and BAG6 overexpression delay OpD degradation; however, our data suggest that th...

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Detalhes bibliográficos
Main Authors: Payapilly, Aishwarya, High, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4075357/
https://ncbi.nlm.nih.gov/pubmed/24806960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.145565
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