Transmembrane helix hydrophobicity is an energetic barrier during the retrotranslocation of integral membrane ERAD substrates

Integral membrane proteins fold inefficiently and are susceptible to turnover via the endoplasmic reticulum–associated degradation (ERAD) pathway. During ERAD, misfolded proteins are recognized by molecular chaperones, polyubiquitinated, and retrotranslocated to the cytoplasm for proteasomal degrada...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Biol Cell
Prif Awduron: Guerriero, Christopher J., Reutter, Karl-Richard, Augustine, Andrew A., Preston, G. Michael, Weiberth, Kurt F., Mackie, Timothy D., Cleveland-Rubeor, Hillary C., Bethel, Neville P., Callenberg, Keith M., Nakatsukasa, Kunio, Grabe, Michael, Brodsky, Jeffrey L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Cell Biology 2017
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509421/
https://ncbi.nlm.nih.gov/pubmed/28539401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E17-03-0184
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