Phosphorylation at S87 Is Enhanced in Synucleinopathies, Inhibits α-Synuclein Oligomerization, and Influences Synuclein-Membrane Interactions

Increasing evidence suggests that phosphorylation may play an important role in the oligomerization, fibrillogenesis, Lewy body (LB) formation, and neurotoxicity of α-synuclein (α-syn) in Parkinson disease. Herein we demonstrate that α-syn is phosphorylated at S87 in vivo and within LBs. The levels...

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Main Authors: Paleologou, Katerina E., Oueslati, Abid, Shakked, Gideon, Rospigliosi, Carla C., Kim, Hai-Young, Lamberto, Gonzalo R., Fernandez, Claudio O., Schmid, Adrian, Chegini, Fariba, Gai, Wei Ping, Chiappe, Diego, Moniatte, Marc, Schneider, Bernard L., Aebischer, Patrick, Eliezer, David, Zweckstetter, Markus, Masliah, Eliezer, Lashuel, Hilal A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947449/
https://ncbi.nlm.nih.gov/pubmed/20203178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5922-09.2010
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