Phosphorylation at S87 Is Enhanced in Synucleinopathies, Inhibits α-Synuclein Oligomerization, and Influences Synuclein-Membrane Interactions

Increasing evidence suggests that phosphorylation may play an important role in the oligomerization, fibrillogenesis, Lewy body (LB) formation, and neurotoxicity of α-synuclein (α-syn) in Parkinson disease. Herein we demonstrate that α-syn is phosphorylated at S87 in vivo and within LBs. The levels...

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Hauptverfasser: Paleologou, Katerina E., Oueslati, Abid, Shakked, Gideon, Rospigliosi, Carla C., Kim, Hai-Young, Lamberto, Gonzalo R., Fernandez, Claudio O., Schmid, Adrian, Chegini, Fariba, Gai, Wei Ping, Chiappe, Diego, Moniatte, Marc, Schneider, Bernard L., Aebischer, Patrick, Eliezer, David, Zweckstetter, Markus, Masliah, Eliezer, Lashuel, Hilal A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2010
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947449/
https://ncbi.nlm.nih.gov/pubmed/20203178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5922-09.2010
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