Phosphorylation at S87 Is Enhanced in Synucleinopathies, Inhibits α-Synuclein Oligomerization, and Influences Synuclein-Membrane Interactions

Increasing evidence suggests that phosphorylation may play an important role in the oligomerization, fibrillogenesis, Lewy body (LB) formation, and neurotoxicity of α-synuclein (α-syn) in Parkinson disease. Herein we demonstrate that α-syn is phosphorylated at S87 in vivo and within LBs. The levels...

詳細記述

保存先:
書誌詳細
主要な著者: Paleologou, Katerina E., Oueslati, Abid, Shakked, Gideon, Rospigliosi, Carla C., Kim, Hai-Young, Lamberto, Gonzalo R., Fernandez, Claudio O., Schmid, Adrian, Chegini, Fariba, Gai, Wei Ping, Chiappe, Diego, Moniatte, Marc, Schneider, Bernard L., Aebischer, Patrick, Eliezer, David, Zweckstetter, Markus, Masliah, Eliezer, Lashuel, Hilal A.
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2010
主題:
Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947449/
https://ncbi.nlm.nih.gov/pubmed/20203178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5922-09.2010
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!

類似資料