Tryptophan/kynurenine metabolism in human leukocytes is independent of superoxide and is fully maintained in chronic granulomatous disease

In chronic granulomatous disease (CGD), defective phagocytic nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity causes reduced superoxide anion (O(2)(˙̄)) radical production leading to frequent infections as well as granulomas and impaired wound healing indicative of excessive infl...

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Main Authors: De Ravin, Suk See, Zarember, Kol A., Long-Priel, Debra, Chan, King C., Fox, Stephen D., Gallin, John I., Kuhns, Douglas B., Malech, Harry L.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2010
Teme:
Phagocytes, Granulocytes, and Myelopoiesis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947395/
https://ncbi.nlm.nih.gov/pubmed/20511543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-233734
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