Tryptophan/kynurenine metabolism in human leukocytes is independent of superoxide and is fully maintained in chronic granulomatous disease

In chronic granulomatous disease (CGD), defective phagocytic nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity causes reduced superoxide anion (O(2)(˙̄)) radical production leading to frequent infections as well as granulomas and impaired wound healing indicative of excessive infl...

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Auteurs principaux: De Ravin, Suk See, Zarember, Kol A., Long-Priel, Debra, Chan, King C., Fox, Stephen D., Gallin, John I., Kuhns, Douglas B., Malech, Harry L.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2010
Sujets:
Phagocytes, Granulocytes, and Myelopoiesis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947395/
https://ncbi.nlm.nih.gov/pubmed/20511543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-233734
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