Tryptophan/kynurenine metabolism in human leukocytes is independent of superoxide and is fully maintained in chronic granulomatous disease

In chronic granulomatous disease (CGD), defective phagocytic nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity causes reduced superoxide anion (O(2)(˙̄)) radical production leading to frequent infections as well as granulomas and impaired wound healing indicative of excessive infl...

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Main Authors: De Ravin, Suk See, Zarember, Kol A., Long-Priel, Debra, Chan, King C., Fox, Stephen D., Gallin, John I., Kuhns, Douglas B., Malech, Harry L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2010
Assuntos:
Phagocytes, Granulocytes, and Myelopoiesis
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947395/
https://ncbi.nlm.nih.gov/pubmed/20511543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-233734
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