Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector–triggered immune responses in vitro and in vivo

Adenovirus (Ad) vectors are widely used in human clinical trials. However, at higher dosages, Ad vector–triggered innate toxicities remain a major obstacle to many applications. Ad interactions with the complement system significantly contribute to innate immune responses in several models of Ad-med...

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Hlavní autoři: Seregin, Sergey S., Aldhamen, Yasser A., Appledorn, Daniel M., Hartman, Zachary C., Schuldt, Nathaniel J., Scott, Jeannine, Godbehere, Sarah, Jiang, Haixiang, Frank, Michael M., Amalfitano, Andrea
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2010
Témata:
Gene Therapy
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947391/
https://ncbi.nlm.nih.gov/pubmed/20511542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-276949
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