Use of DAF-Displaying Adenovirus Vectors Reduces Induction of Transgene- and Vector-Specific Adaptive Immune Responses in Mice

Adenovirus (Ad)-based vectors are attractive candidates for a variety of gene-transfer applications. In this study, we found that decay-accelerating factor (DAF)–displaying Ads induce significantly decreased cellular immune responses to transgenes expressed from the vectors in both Ad5-naive and Ad5...

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Bibliographic Details
Main Authors: Seregin, Sergey S., Aldhamen, Yasser A., Appledorn, Daniel M., Zehnder, Jennifer, Voss, Tyler, Godbehere, Sarah, Amalfitano, Andrea
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2011
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177950/
https://ncbi.nlm.nih.gov/pubmed/21388344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2010.218
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