Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector–triggered immune responses in vitro and in vivo

Adenovirus (Ad) vectors are widely used in human clinical trials. However, at higher dosages, Ad vector–triggered innate toxicities remain a major obstacle to many applications. Ad interactions with the complement system significantly contribute to innate immune responses in several models of Ad-med...

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Detalhes bibliográficos
Main Authors: Seregin, Sergey S., Aldhamen, Yasser A., Appledorn, Daniel M., Hartman, Zachary C., Schuldt, Nathaniel J., Scott, Jeannine, Godbehere, Sarah, Jiang, Haixiang, Frank, Michael M., Amalfitano, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947391/
https://ncbi.nlm.nih.gov/pubmed/20511542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-276949
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