Sublingual Administration of an Adenovirus Serotype 5 (Ad5)-Based Vaccine Confirms Toll-Like Receptor Agonist Activity in the Oral Cavity and Elicits Improved Mucosal and Systemic Cell-Mediated Responses against HIV Antigens despite Preexisting Ad5 Immunity

HIV/AIDS continue to devastate populations worldwide. Recent studies suggest that vaccines that induce beneficial immune responses in the mucosal compartment may improve the efficacy of HIV vaccines. Adenovirus serotype 5 (Ad5)-based vectors remain a promising platform for the development of effecti...

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Detalhes bibliográficos
Main Authors: Appledorn, Daniel M., Aldhamen, Yasser A., Godbehere, Sarah, Seregin, Sergey S., Amalfitano, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Vaccine Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019785/
https://ncbi.nlm.nih.gov/pubmed/21084461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00341-10
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