A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

Phosphoinositide 3-kinases (PI3-Ks) are an important emerging class of drug targets, but the unique roles of PI3-K isoforms remain poorly defined. We describe here an approach to pharmacologically interrogate the PI3-K family. A chemically diverse panel of PI3-K inhibitors was synthesized, and their...

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書誌詳細
主要な著者: Knight, Zachary A., Gonzalez, Beatriz, Feldman, Morri E., Zunder, Eli R., Goldenberg, David D., Williams, Olusegun, Loewith, Robbie, Stokoe, David, Balla, Andras, Toth, Balazs, Balla, Tamas, Weiss, William A., Williams, Roger L., Shokat, Kevan M.
フォーマット: Artigo
言語:Inglês
出版事項: 2006
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946820/
https://ncbi.nlm.nih.gov/pubmed/16647110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2006.03.035
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