A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

Phosphoinositide 3-kinases (PI3-Ks) are an important emerging class of drug targets, but the unique roles of PI3-K isoforms remain poorly defined. We describe here an approach to pharmacologically interrogate the PI3-K family. A chemically diverse panel of PI3-K inhibitors was synthesized, and their...

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Autors principals: Knight, Zachary A., Gonzalez, Beatriz, Feldman, Morri E., Zunder, Eli R., Goldenberg, David D., Williams, Olusegun, Loewith, Robbie, Stokoe, David, Balla, Andras, Toth, Balazs, Balla, Tamas, Weiss, William A., Williams, Roger L., Shokat, Kevan M.
Format: Artigo
Idioma:Inglês
Publicat: 2006
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946820/
https://ncbi.nlm.nih.gov/pubmed/16647110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2006.03.035
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