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A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling
Phosphoinositide 3-kinases (PI3-Ks) are an important emerging class of drug targets, but the unique roles of PI3-K isoforms remain poorly defined. We describe here an approach to pharmacologically interrogate the PI3-K family. A chemically diverse panel of PI3-K inhibitors was synthesized, and their...
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| Main Authors: | , , , , , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2006
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2946820/ https://ncbi.nlm.nih.gov/pubmed/16647110 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2006.03.035 |
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