A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

Phosphoinositide 3-kinases (PI3-Ks) are an important emerging class of drug targets, but the unique roles of PI3-K isoforms remain poorly defined. We describe here an approach to pharmacologically interrogate the PI3-K family. A chemically diverse panel of PI3-K inhibitors was synthesized, and their...

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Bibliographic Details
Main Authors: Knight, Zachary A., Gonzalez, Beatriz, Feldman, Morri E., Zunder, Eli R., Goldenberg, David D., Williams, Olusegun, Loewith, Robbie, Stokoe, David, Balla, Andras, Toth, Balazs, Balla, Tamas, Weiss, William A., Williams, Roger L., Shokat, Kevan M.
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946820/
https://ncbi.nlm.nih.gov/pubmed/16647110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2006.03.035
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