Role of lipid metabolism in Smoothened de-repression in Hedgehog signaling

The binding of Hedgehog to its receptor Patched causes de-repression of Smoothened resulting in the activation of the Hedgehog pathway. Here, we show that Smo activation is dependent on the levels of phospholipid, Phosphatidyl Inositol-4 Phosphate (PI4P). Loss of STT4 kinase required for the generat...

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Autori principali: Yavari, Amir, Nagaraj, Raghavendra, Owusu-Ansah, Edward, Folick, Andrew, Ngo, Kathy, Hillman, Tyler, Call, Gerald, Rohatgi, Rajat, Scott, Matthew P., Banerjee, Utpal
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945252/
https://ncbi.nlm.nih.gov/pubmed/20643350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2010.06.007
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