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Role of lipid metabolism in Smoothened de-repression in Hedgehog signaling
The binding of Hedgehog to its receptor Patched causes de-repression of Smoothened resulting in the activation of the Hedgehog pathway. Here, we show that Smo activation is dependent on the levels of phospholipid, Phosphatidyl Inositol-4 Phosphate (PI4P). Loss of STT4 kinase required for the generat...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2945252/ https://ncbi.nlm.nih.gov/pubmed/20643350 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2010.06.007 |
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