Role of lipid metabolism in Smoothened de-repression in Hedgehog signaling

The binding of Hedgehog to its receptor Patched causes de-repression of Smoothened resulting in the activation of the Hedgehog pathway. Here, we show that Smo activation is dependent on the levels of phospholipid, Phosphatidyl Inositol-4 Phosphate (PI4P). Loss of STT4 kinase required for the generat...

Fuld beskrivelse

Na minha lista:

Bibliografiske detaljer
Main Authors:	Yavari, Amir, Nagaraj, Raghavendra, Owusu-Ansah, Edward, Folick, Andrew, Ngo, Kathy, Hillman, Tyler, Call, Gerald, Rohatgi, Rajat, Scott, Matthew P., Banerjee, Utpal
Format:	Artigo
Sprog:	Inglês
Udgivet:	2010
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2945252/ https://ncbi.nlm.nih.gov/pubmed/20643350 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2010.06.007
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!

Role of lipid metabolism in Smoothened de-repression in Hedgehog signaling

Lignende værker