Expression, Purification, and Characterization of Aspergillus fumigatus Sterol 14-α Demethylase (CYP51) Isoenzymes A and B

Aspergillus fumigatus sterol 14-α demethylase (CYP51) isoenzymes A (AF51A) and B (AF51B) were expressed in Escherichia coli and purified. The dithionite-reduced CO-P450 complex for AF51A was unstable, rapidly denaturing to inactive P420, in marked contrast to AF51B, where the CO-P450 complex was sta...

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Hlavní autoři: Warrilow, Andrew G. S., Melo, Nadja, Martel, Claire M., Parker, Josie E., Nes, W. David, Kelly, Steven L., Kelly, Diane E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2010
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944604/
https://ncbi.nlm.nih.gov/pubmed/20660663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00316-10
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