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Foxa1 and Foxa2 Maintain the Metabolic and Secretory Features of the Mature β-Cell
Foxa1 and Foxa2 play both redundant and distinct roles in early pancreas development. We demonstrate here that inducible ablation of both transcription factors in mature mouse β-cells leads to impaired glucose homeostasis and insulin secretion. The defects in both glucose-stimulated insulin secretio...
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Main Authors: | , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
The Endocrine Society
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2940470/ https://ncbi.nlm.nih.gov/pubmed/20534694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2009-0513 |
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