Foxa1 and Foxa2 Maintain the Metabolic and Secretory Features of the Mature β-Cell

Foxa1 and Foxa2 play both redundant and distinct roles in early pancreas development. We demonstrate here that inducible ablation of both transcription factors in mature mouse β-cells leads to impaired glucose homeostasis and insulin secretion. The defects in both glucose-stimulated insulin secretio...

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Autores principales: Gao, Nan, Le Lay, John, Qin, Wei, Doliba, Nicolai, Schug, Jonathan, Fox, Alan J., Smirnova, Olga, Matschinsky, Franz M., Kaestner, Klaus H.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Endocrine Society 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940470/
https://ncbi.nlm.nih.gov/pubmed/20534694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2009-0513
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