Foxa1 and Foxa2 Maintain the Metabolic and Secretory Features of the Mature β-Cell

Foxa1 and Foxa2 play both redundant and distinct roles in early pancreas development. We demonstrate here that inducible ablation of both transcription factors in mature mouse β-cells leads to impaired glucose homeostasis and insulin secretion. The defects in both glucose-stimulated insulin secretio...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Gao, Nan, Le Lay, John, Qin, Wei, Doliba, Nicolai, Schug, Jonathan, Fox, Alan J., Smirnova, Olga, Matschinsky, Franz M., Kaestner, Klaus H.
Formato: Artigo
Idioma:Inglês
Publicado: The Endocrine Society 2010
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940470/
https://ncbi.nlm.nih.gov/pubmed/20534694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2009-0513
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares