Probing the Role of CXC Motif in Chemokine CXCL8 for High Affinity Binding and Activation of CXCR1 and CXCR2 Receptors

All chemokines share a common structural scaffold that mediate a remarkable variety of functions from immune surveillance to organogenesis. Chemokines are classified as CXC or CC on the basis of conserved cysteines, and the two subclasses bind distinct sets of GPCR class of receptors and also have m...

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Main Authors: Joseph, Prem Raj B., Sarmiento, Jose M., Mishra, Anurag K., Das, Sandhya T., Garofalo, Roberto P., Navarro, Javier, Rajarathnam, Krishna
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937958/
https://ncbi.nlm.nih.gov/pubmed/20630874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.146555
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