Smad2 Positively Regulates the Generation of Th17 Cells

Development of Foxp3(+) regulatory T cells and pro-inflammatory Th17 cells from naive CD4(+) T cells requires transforming growth factor-β (TGF-β) signaling. Although Smad4 and Smad3 have been previously shown to regulate Treg cell induction by TGF-β, they are not required in the development of Th17...

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Autors principals: Martinez, Gustavo J., Zhang, Zhengmao, Reynolds, Joseph M., Tanaka, Shinya, Chung, Yeonseok, Liu, Ting, Robertson, Elizabeth, Lin, Xia, Feng, Xin-Hua, Dong, Chen
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
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Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937933/
https://ncbi.nlm.nih.gov/pubmed/20667820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C110.155820
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