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SMAD2 Is Essential for TGFβ-mediated Th17 Cell Generation
TGFβ is the quintessential cytokine of T cell homeostasis. TGFβ signaling is required for the efficient differentiation and maintenance of CD4(+)FOXP3(+) T cells that inhibit immune responses. Conversely, in conjunction with the inflammatory cytokine IL-6, TGFβ promotes Th17 cell differentiation. Th...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2937934/ https://ncbi.nlm.nih.gov/pubmed/20656683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C110.156745 |
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