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Complementary Roles for Exonuclease 1 and Flap Endonuclease 1 in Maintenance of Triplet Repeats

Trinucleotide repeats can form stable secondary structures that promote genomic instability. To determine how such structures are resolved, we have defined biochemical activities of the related RAD2 family nucleases, FEN1 (Flap endonuclease 1) and EXO1 (exonuclease 1), on substrates that recapitulat...

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Bibliografiske detaljer
Main Authors: Vallur, Aarthy C., Maizels, Nancy
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937877/
https://ncbi.nlm.nih.gov/pubmed/20643645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.132738
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