Saccharomyces cerevisiae Flap Endonuclease 1 Uses Flap Equilibration To Maintain Triplet Repeat Stability

Flap endonuclease 1 (FEN1) is a central component of Okazaki fragment maturation in eukaryotes. Genetic analysis of Saccharomyces cerevisiae FEN1 (RAD27) also reveals its important role in preventing trinucleotide repeat (TNR) expansion. In humans such expansion is associated with neurodegenerative...

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Detalhes bibliográficos
Main Authors: Liu, Yuan, Zhang, Haihua, Veeraraghavan, Janaki, Bambara, Robert A., Freudenreich, Catherine H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC387768/
https://ncbi.nlm.nih.gov/pubmed/15082797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.9.4049-4064.2004
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