Saccharomyces cerevisiae Flap Endonuclease 1 Uses Flap Equilibration To Maintain Triplet Repeat Stability

Flap endonuclease 1 (FEN1) is a central component of Okazaki fragment maturation in eukaryotes. Genetic analysis of Saccharomyces cerevisiae FEN1 (RAD27) also reveals its important role in preventing trinucleotide repeat (TNR) expansion. In humans such expansion is associated with neurodegenerative...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Liu, Yuan, Zhang, Haihua, Veeraraghavan, Janaki, Bambara, Robert A., Freudenreich, Catherine H.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2004
Soggetti:	DNA Dynamics and Chromosome Structure
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC387768/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15082797/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.9.4049-4064.2004
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