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Saccharomyces cerevisiae Flap Endonuclease 1 Uses Flap Equilibration To Maintain Triplet Repeat Stability

Flap endonuclease 1 (FEN1) is a central component of Okazaki fragment maturation in eukaryotes. Genetic analysis of Saccharomyces cerevisiae FEN1 (RAD27) also reveals its important role in preventing trinucleotide repeat (TNR) expansion. In humans such expansion is associated with neurodegenerative...

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Udgivet i:Mol Cell Biol
Principais autores: Liu, Yuan, Zhang, Haihua, Veeraraghavan, Janaki, Bambara, Robert A., Freudenreich, Catherine H.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2004
Fag:
DNA Dynamics and Chromosome Structure
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC387768/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15082797/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.9.4049-4064.2004
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