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Curcumin Decreases Amyloid-β Peptide Levels by Attenuating the Maturation of Amyloid-β Precursor Protein

Alzheimer disease (AD) is a devastating neurodegenerative disease with no cure. The pathogenesis of AD is believed to be driven primarily by amyloid-β (Aβ), the principal component of senile plaques. Aβ is an ∼4-kDa peptide generated via cleavage of the amyloid-β precursor protein (APP). Curcumin is...

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מידע ביבליוגרפי
Main Authors: Zhang, Can, Browne, Andrew, Child, Daniel, Tanzi, Rudolph E.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937872/
https://ncbi.nlm.nih.gov/pubmed/20622013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.133520
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